Ethyl bromoacetate → HCID 10457478, compound

HRID 620600Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:7])[CH2:5]Br)[CH3:2].[C:8]1([CH2:14][O:15][C:16]([NH:18][CH:19]2[N:25]=[C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:23]3[CH:32]=[CH:33][CH:34]=[CH:35][C:22]=3[NH:21][C:20]2=[O:36])=[O:17])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[CH2:1]([O:3][C:4](=[O:7])[CH2:5][N:21]1[C:22]2[CH:35]=[CH:34][CH:33]=[CH:32][C:23]=2[C:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[N:25][CH:19]([NH:18][C:16]([O:15][CH2:14][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[O:17])[C:20]1=[O:36])[CH3:2]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 2756242Benzyl (2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)carbamate

Product 1

HCID 10457478HCID 10457478, compound

Procedure

The procedure of Example 4 was employed using equimolar amounts of ethylbromoacetate and 1,3-dihydro-3(R,S)-(phenylmethyloxycarbonyl)amino-5-phenyl-2H-1,4-benzodiazepin-2-one. The chromatographed product (ethyl acetate-hexane) was dried in vacuo at room temperature over P2O5 : m.p. 65°-66° C.

Workup

dry with materialThe chromatographed product (ethyl acetate-hexane) was dried in vacuo at room temperature over P2O5

Sources & evidence

ORD record: ord-cfce06780316472b80086db7128834fd
Source dataset: uspto-grants-1989_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04820834

Reaction notes

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