反应详情

The procedure of Example 134 was carried out employing equivalent amounts of 1,3-dihydro-1-methyl-3(RS)-amino-5-phenyl-2H-1,4-benzodiazepin-2-one and 4-bromobenzoyl chloride. The product was purified by chromatography on silica gel (5% (v/v) Et2O in CH2Cl2 elution). The combined product fractions were evaporated to dryness in vacuo and crystallized to give the title compound which was dried at 65° C.

1. customThe product was purified by chromatography on silica gel (5% (v/v) Et2O in CH2Cl2 elution)
2. customThe combined product fractions were evaporated to dryness in vacuo
3. customcrystallized