4-Chlorophenylacetyl chloride → HCID 14208224, compound

HRID 620615Notes

Reaction equation

HRID 620615 reaction equation
[NH2:1][CH:2]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[NH:4][C:3]1=[O:19].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](Cl)=[O:29])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][CH:2]2[N:8]=[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:6]3[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=3[NH:4][C:3]2=[O:19])=[O:29])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 42596493-Amino-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

Product 1

HCID 14208224HCID 14208224, compound

Procedure

The procedure of Example 134 was carried out using equivalent amounts of 3(R,S)-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one and 4-chlorophenylacetyl chloride. The product was purified by chromatography on silica gel (hexane-ethyl acetate elution). The combined product fractions were evaporated to dryness in vacuo and crystallized to give the title compound which was dried at 65° C: m.p. 238°-240° C.

Workup

  1. customThe product was purified by chromatography on silica gel (hexane-ethyl acetate elution)
  2. customThe combined product fractions were evaporated to dryness in vacuo
  3. customcrystallized

Sources & evidence

ORD record
ord-bf87723215b34919915f0d7cf418a8c1
Source dataset
uspto-grants-1989_04
Patent number
US04820834

Reaction notes

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