HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 15614797, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Methoxyphenyl isocyanate | HCID 87843 | — |
| Reactant | HCID 15167833 | HCID 15167833 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 15614797 | HCID 15614797 | — |
Reaction Steps
Equimolar amounts of 3-(R,S)-amino-1,3-dihydro-1,9-dimethyl-5-phenyl-2H-1,4-benzodiazepin-2-one, 3-methoxyphenylisocyanate and triethylamine were mixed in THF at 0° C. and stirred 20 minutes. Removal of THF in vacuo, dissolution of the residue in CH2Cl2 and flash chromatography on silica gel (12% Et2O in CH2Cl2) gave the title compound which was crystallized as a white fluffy solid from Et2O: m.p. 215°-217° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820834 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-f3bc20f31e024e98a3fcb85e47ee0845 |
| Source note | uspto-grants-1989_04 |