Ethyl Acetate → 2,2,5,5-Tetramethylcyclopentan-1-ol

Beteiligte Stoffe

Reaktionsschritte

To a magnetically stirred solution of 10 g (0.071 mol) 2,2,5,5-tetramethycyclopentanone in 75 ml of dry tetrahydrofuran at 0° C. under argon is added 2.69 g (0.071 mol) of lithium aluminum hydride. When the reduction was complete, ethyl acetate was introduced dropwise to destroy unreacted lithium aluminum hydride. 25 mls of water is then added, followed by 300 mls of diethyl ether. The organic phase is washed into 100 mls of water, and dried over MgSO4. Filtration followed by evaporation afforded 8.23 g of 2,2,5,5-tetramethylcyclopentanol.

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