Ammonia → HCID 54440118, compound

Participants

Reaction Steps

A solution of (2S,4R)-1-t-butoxycarbonyl-4-t-butyl dimethylsilyloxy-2-(methoxycarbonylmethyloxymethyl)pyrrolidine (0.75 g) in methanol (21 ml) was saturated with ammonia at ambient temperature and the solution was stirred at the same temperature for 5 hours. The mixture was concentrated under reduced pressure to give a syrup. The syrup was subjected to a column chromatography on silica gel (15 g) and eluted with a mixture of methanol and chloroform (1:99 V/V) to give (2S,4R)-1-t-butoxycarbonyl-4-t-butyldimethylsilyloxy-2-(carbamoylmethyloxymethyl)pyrrolidine (0.61 g).

Provenance & Evidence