2,4-Dimethoxybenzaldehyde → 1-Hydroxy-2-(2,4-dimethoxyphenyl)-5-methyl-4-(4-pyridyl)imidazole

Participants

Reaction Steps

To a suspension of 4-(2-hydroxyiminopropionyl)pyridine (2.0 g) in a mixture of dioxane (40 ml) and ethanol were added conc. ammonia water (58 ml) and 2,4-dimethoxybenzaldehyde (2.02 g), and the mixture was stirred at ambient temperature for 1 week. After evaporation, the mixture was triturated with chloroform to give 1-hydroxy-2-(2,4-dimethoxyphenyl)-5-methyl-4-(4-pyridyl)imidazole (3.01 g).

Provenance & Evidence