Water → HCID 14211364, compound

Participants

Reaction Steps

A solution of 2-(4-acetamido-5-chloro-2-methoxyphenyl)-5-methyl-4-(3-pyridyl)imidazole (1.0 g) in 10% hydrochloric acid (30 ml) was stirred at 80° to 85° C. for 4 hours. The reaction mixture was poured into water (100 ml) and washed with ethyl acetate. The solution was adjusted to pH 8.0 with 20% potassium carbonate and extracted with ethyl acetate. The extract was washed with brine and dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was crystallized from a mixture of ethyl acetate and diethyl ether to give 2-(4-amino-5-chloro-2-methoxyphenyl)-5-methyl-4-(3-pyridyl)imidazole (0.63 g).

Provenance & Evidence