Hydrochloric Acid → HCID 10016509, compound

Participants

Reaction Steps

A solution of 2-(4-acetamido-2-methoxyphenyl)-5-methyl-4-(3-pyridyl)imidazole (0.55 g) in 1N-hydrochloric acid (25 ml) was refluxed for 5.5 hours, and cooled. After neutralized with aqueous sodium bicarbonate, the mixture was extracted with chloroform. The extract was dried over sodium sulfate, evaporated, and the residue was triturated with a mixture of methanol and diisopropyl ether to give 2-(4-amino-2-methoxyphenyl)-5-methyl-4-(3-pyridyl)imidazole (0.24 g).

Provenance & Evidence