Acetic Anhydride → HCID 178474111, compound

HRID 620835Notes

Reaction equation

HRID 620835 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:9][C:10]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[C:11]([CH3:13])[N:12]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>C(O)(=O)C>[C:20]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:9][C:10]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[C:11]([CH3:13])[N:12]=1)(=[O:22])[CH3:21]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178432492HCID 178432492, compound

Product 1

HCID 178474111HCID 178474111, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2-(2-aminophenyl)-4-methyl-5-(3-pyridyl)imidazole (0.5 g) and acetic anhydride (0.38 ml) in acetic acid (5 ml) was stirred at ambient temperature for 1.5 hours. The resulting precipitate was collected by filtration, and recrystallized from ethanol to give 2-(2-acetamidophenyl)-4-methyl-5-(3-pyridyl)imidazole (0.55 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-1f539a44b27240fabeafda6ff439218c
Source dataset
uspto-grants-1989_04
Patent number
US04822805

Reaction notes

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