2-Ethyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]nonane dihydrochloride → 2-Ethyl-2,7-diazaspiro[4.4]nonane dihydrochloride

HRID 620868Notes

Reaction equation

HRID 620868 reaction equation
[ClH:1].Cl.[CH2:3]([N:10]1[CH2:14][CH2:13][C:12]2([CH2:18][CH2:17][N:16](CC)[CH2:15]2)[CH2:11]1)[C:4]1C=CC=CC=1>CO.[Pd]>[ClH:1].[ClH:1].[CH2:3]([N:10]1[CH2:14][CH2:13][C:12]2([CH2:18][CH2:17][NH:16][CH2:15]2)[CH2:11]1)[CH3:4]

Participants

4

Reactant 1

HCID 134918102-Ethyl-7-(phenylmethyl)-2,7-diazaspiro[4.4]nonane dihydrochloride

Product 1

HCID 134918112-Ethyl-2,7-diazaspiro[4.4]nonane dihydrochlorideYield 196.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 9.5 g (0.03 mole) 2-benzyl-7-ethyl-2,7-diazaspiro[4.4]nonane dihydrochloride in 100 ml methanol was hydrogenated with 1.0 g 20% palladium on carbon catalyst at 4.5×105 Pa for 22 hours. After filtration, the solution was concentrated to a syrup and crystallized from acetonitrile to afford 6.7 g of the title compound, mp 168°-172° C.

Workup

  1. filtrationAfter filtration
  2. concentrationthe solution was concentrated to a syrup
  3. customcrystallized from acetonitrile

Sources & evidence

ORD record
ord-45330e10a3424b6ca50511245fbb8074
Source dataset
uspto-grants-1989_04
Patent number
US04822801

Reaction notes

Loading…