Trifluoroacetic acid → HCID 23260547, compound

Participants

Reaction Steps

A solution of ethylene acetal of 3,4-dihydro-11-chloro6,7-dihydroxy-2,5,12(1H)-naphthacenetrione (compound 11) (4 mg) in trifluoroacetic acid (2 ml) was heated at 80° under reflux for 1 h. The solution was cooled, diluted with distilled water (10 ml) and extracted with ethyl acetate. The combined organic layers were washed with distilled water, dried and evaporated to give the crude product (compound 8) which was recrystallized from ethyl acetate as brown microcrystals (2.5 mg 74%).

Provenance & Evidence