Sodium Methoxide → HCID 21245515, compound

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Reaction Steps

11.1 g of the product obtained by Method D are dissolved in 50 ml of methyl formate, and the solution is slowly added at 0° C. to 3.5 g of sodium methylate. The mixture is warmed to room temperature, and the bulk of the methyl formate is removed under reduced pressure. The remainder is poured onto cold 2N NaOH, and the mixture is extracted with 30 ml of methyl t-butyl ether. The aqueous phase is acidified, and the methyl α-formyl(2-butoxyphenyl)acetate is extracted with dichloromethane. Drying the organic phase over Na2SO4 gives 10.2 g (82%) of pure product.

Provenance & Evidence