Acetophenone → 1-(3-Vinylphenyl)-1-phenylethyl alcohol

Participants

Reaction Steps

A method to use acetophenone (formula VIII) as a starting material is described. Acetophenone is reacted with a Grignard reagent of 3-vinylphenylmagnesium bromide (formula VII) to obtain 1-(3-vinylphenyl)-1-phenylethyl alcohol (formula V) (hereinafter referred to as "VPA"). The reaction product is then dehydrated in the presence of potassium hydrogensulfate to form 1-(3-vinylphenyl)-1-phenylethylene (formula I). This Grignard addition reaction is carried out at a temperature in the range of 0° to 100° C., preferably 20° to 80° C. The dehydration is carried out at 170° to 250° C., preferably 190° to 230° C., under a reduced pressure. The quantity of Grignard reagent is 1.0 to 1.2 equivalents relative to the acetophenone. ##STR7##

Provenance & Evidence