HRID621166

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O

HCID2724765

L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-

C19H28N2O6

HCID13132278

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CN(C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C)C1Cc2ccccc2C1

HCID13132294

未命名化合物

收率 69.3%

PROCEDURE

实验过程

By reacting 8.2 g of N-(indan-2-yl)glycine tert-butyl ester with 13 g of Nα -tert-butoxycarbonyl-Nε -carbobenzoxy-L-lysine as in Reference Example 5, there is obtained 14 g of Nα -tert-butoxycarbonyl-Nε -carbobenzoxy-L-lysyl-N-(indan-2-yl)glycine tert-butyl ester as a colorless oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f71242741f9944ff8aa39e79aeed304a
来源数据集: uspto-grants-1989_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04822818
来源说明: uspto-grants-1989_04

反应 SMILES

[C:1]([O:5][C:6](=[O:18])[CH2:7][NH:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[C:19]([O:23][C:24]([NH:26][C@H:27]([C:43](O)=[O:44])[CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]([O:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:1]([O:5][C:6](=[O:18])[CH2:7][N:8]([C:43](=[O:44])[C@H:27]([CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]([O:35][CH2:36][C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)=[O:34])[NH:26][C:24]([O:23][C:19]([CH3:22])([CH3:20])[CH3:21])=[O:25])[CH:9]1[CH2:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:17]1)([CH3:4])([CH3:2])[CH3:3]