HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 9-(Phenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | HCID 178484237 | HCID 178484237 | — |
| Solvent | Dichloromethane ethylacetate | HCID 21226138 | — |
| Product | 9-(Phenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile | HCID 90410642 | 67% |
Reaction Steps
Prepared from VII and aniline. Flash chromatography eluent (DCM-EtOAc, 5:5). Yield: 67%; yellow solid; mp>260° C.; IR (KBr) νmax/cm−1 3395, 3057, 2228, 1731, 1644, 1608, 1577, 1491, 1459, 1378, 1352, 1301, 1255, 1214, 1147, 1128, 1106, 1071, 967, 896, 827; 1H NMR (300 MHz, DMSO-d6) δ 8.51 (d, 1H, J=9.0 Hz), 8.11 (s, 1H), 7.78 (d, 1H, J=9.0 Hz), 7.40 (t, 2H, J=7.5 Hz), 7.20 (m, 2H), 7.11 (t, 1H, J=7.5 Hz); HRMS calcd for C16H10N5S (M+H+): 304.0657, found 304.0657.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09446044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-514b5bb11f9d45089f8e7b66d0a7891c |
| Source note | uspto-grants-2016_09 |