HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluidine → 9-(p-Tolylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluidine | HCID 7813 | — |
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | HCID 178484237 | HCID 178484237 | — |
| Solvent | Dichloromethane ethylacetate | HCID 21226138 | — |
| Product | 9-(p-Tolylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile | HCID 71277783 | 64% |
Reaction Steps
Prepared from VII and 4-toluidine. Flash chromatography eluent (DCM-EtOAc, 7:3). Yield: 64%; yellow solid; mp>260° C.; IR (KBr) νmax/cm−1 3016, 2853, 2228, 1731, 1641, 1605, 1581, 1554, 1505, 1458, 1376, 1353, 1304, 1268, 1215, 1165, 1130, 976, 831, 811; 1H NMR (300 MHz, DMSO-d6) δ 8.49 (d, 1H, J=9.0 Hz), 8.07 (s, 1H), 7.76 (d, 1H, J=9.0 Hz), 7.20-7.17 (m, 2H), 7.12-7.05 (m, 2H), 2.32 (s, 3H); HRMS calcd for C17H12N5S (M+H+): 318.0813, found 318.0811.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09446044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-3fe1b9cfa3a94183ac5a08b02ce7cecf |
| Source note | uspto-grants-2016_09 |