Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Bromide → 9-(2-Fluoro-4-methoxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Bromide | HCID 253877 | — |
| 반응물 | 2-Fluoro-4-methoxyaniline | HCID 3756383 | — |
| 반응물 | HCID 178484237 | HCID 178484237 | — |
| 용매 | Dichloromethane ethylacetate | HCID 21226138 | — |
| 생성물 | 9-(2-Fluoro-4-methoxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile | HCID 71277778 | 85% |
반응 단계
Prepared from VII and 2-fluoro-4-methoxyaniline. Flash chromatography eluent (DCM-EtOAc, 5:5). Yield: 85%; yellow solid; mp>260° C.; IR (KBr) νmax/cm−1 2844, 2226, 1731, 1649, 1613, 1583, 1507, 1493, 1460, 1445, 1379, 1356, 1305, 1263, 1212, 1168, 1153, 1129, 1090, 1027, 980, 947, 841, 830, 818; 19F NMR (282 MHz, DMSO-d6) δ −120.02; 1H NMR (300 MHz, DMSO-d6) δ 8.51 (d, 1H, J=9.0 Hz), 8.15 (s, 1H), 7.77 (d, 1H, J=9.0 Hz), 7.30 (s, 1H), 6.92 (m, 1H), 6.80 (d, 2H, J=9.0 Hz); HRMS calcd for C17H11N5OSF (M+H+): 352.0668, found 352.0658.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09446044B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-e4e17aee01ea4d63bcfbcce3a99bca56 |
| 출처 메모 | uspto-grants-2016_09 |