HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 4-methoxy-3-nitro- → 9-(4-Methoxy-3-nitrophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 4-methoxy-3-nitro- | HCID 123071 | — |
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | HCID 178484237 | HCID 178484237 | — |
| Solvent | Dichloromethane ethylacetate | HCID 21226138 | — |
| Product | 9-(4-Methoxy-3-nitrophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile | HCID 71277770 | 61% |
Reaction Steps
Prepared from VII and 3-nitro-4-methoxyaniline. Flash chromatography eluent (DCM-EtOAc, 7:3). Yield: 61%; yellow solid; mp 200-260° C.; IR (KBr) νmax/cm−1 2226, 1644, 1523, 1459, 1346, 1267, 1191, 1155, 1075, 1015, 970, 928, 890, 822; 1H NMR (300 MHz, DMSO-d6) δ 8.47 (d, 1H, J=9.0 Hz), 8.26 (s, 1H), 7.97 (d, 1H, J=9.0 Hz), 7.70 (s, 2H), 7.32 (d, 1H, J=9.0 Hz), 3.93 (s, 3H); HRMS calcd for C17H11N6O3S (M+H+): 379.0613, found 379.0614.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09446044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-623bf30e41ce4fd68b08f0d16d40103d |
| Source note | uspto-grants-2016_09 |