HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Tert-Butylaniline → 9-(4-tert-Butylbenzylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Tert-Butylaniline | HCID 69861 | — |
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | Dichloromethane ethylacetate | HCID 21226138 | — |
| Reactant | HCID 178484237 | HCID 178484237 | — |
| Product | 9-(4-tert-Butylbenzylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile | HCID 90411030 | 99% |
Reaction Steps
Prepared from VII and 4-tert-butylaniline. Flash chromatography eluent (DCM-EtOAc, 7:3). Yield: 99%; yellow solid; mp 154° C.; IR (KBr) νmax/cm−1 2958, 2235, 1693, 1649, 1582, 1505, 1466, 1408, 1349, 1288, 1219, 1155, 1125, 989, 968, 894, 831; 1H NMR (300 MHz, DMSO-d6) δ 8.49 (d, 1H, J=9.0 Hz), 8.07 (s, 1H), 7.76 (d, 1H, J=9.0 Hz), 7.40 (d, 2H, J=7.8 Hz), 7.12 (m, 2H), 1.31 (s, 9H); HRMS calcd for C20H18N5S (M+H+): 360.1283, found 360.1273.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09446044B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-653b5db35a2840e38d56eee18598e83b |
| Source note | uspto-grants-2016_09 |