HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-(m-Chlorophenyl)-3-isovaleroyl-5-ethyl-1,3-oxazolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Isovaleryl chloride | HCID 66054 | — |
| Reactant | 2-(m-Chlorophenyl)-5-ethyl-1,3-oxazolidine | HCID 15614615 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(m-Chlorophenyl)-3-isovaleroyl-5-ethyl-1,3-oxazolidine | HCID 15614617 | — |
Reaction Steps
Four and two-tenths grams of 2-(m-chlorophenyl)-5-ethyl-1,3-oxazolidine was combined with 1.7 g of pyridine in 25 ml of methylene chloride and 2.4 g of isovaleroyl chloride was added dropwise with stirring and the mixture was stirred overnight. The mixture was washed with 50 ml of 5% NaOH and 200 ml of water, dried with MgSO4 and stripped under vacuum. The yield was 2.4 g, nD30 1.5490. The structure was confirmed by NMR and infrared spectroscopy.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04824468 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-e81a5fbc53ac44489b87356fdcb3957c |
| Source note | uspto-grants-1989_04 |