反应详情

A mixture of 82.2 parts of methyl N-(decahydro-1-naphthalenyl)glycine, 36 parts of formic acid and 360 parts of methylbenzene was stirred for 4 hours at reflux temperature, using a water separator (another portion of 36 parts of formic acid was added each hour). After cooling, the separated organic layer was washed with a formic acid solution 20% and a sodium hydrogen carbonate solution, dried, filtered and evaporated, yielding 66 parts (71.3%) of methyl N-(decahydro-1-naphthalenyl)-N-formylglycine as a residue (intermediate 2).

1. temperatureat reflux temperature
2. additionwas added each hour)
3. temperatureAfter cooling
4. washthe separated organic layer was washed with a formic acid solution 20%
5. dry with materiala sodium hydrogen carbonate solution, dried
6. filtrationfiltered
7. customevaporated