Ethylene Glycol → HCID 178444386, compound

Participants

Reaction Steps

KOH (9.5 g, 0.17 mol) and ethylene glycol (100 ml) were added to 2-(trans-4-pentylcyclohexyl)-5-methoxypyrimidine (7.4 g, 0.028 mol) prepared in the same manner as in Example 1, followed by heating the mixture under reflux with stirring for 3 hours, cooling the resulting material, adding glacial acetic acid (30 ml) thereto, further adding water (100 ml), filtering the reaction mixture under suction through a filter, sufficiently washing the residue on the filter with water, three times recrystallizing the residue from ethanol and removing ethanol under reduced pressure to obtain 2-(trans-4-pentylcyclohexyl)-5-hydroxypyrimidine (4.9 g, 0.020 mol) having a melting point of 190.0°~191.1° C.

Provenance & Evidence