Benzenepropanoyl chloride → HCID 1787923, compound

HRID 621405Notes

Reaction equation

HRID 621405 reaction equation
[C:1]([O:5][CH3:6])(=[O:4])[NH:2][NH2:3].[C:7]1([CH2:13][CH2:14][C:15](Cl)=[O:16])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(#N)C>[C:7]1([CH2:13][CH2:14][C:15]([NH:3][NH:2][C:1]([O:5][CH3:6])=[O:4])=[O:16])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 64801Benzenepropanoyl chlorideHCID 80519Methyl carbazate

Product 1

HCID 1787923HCID 1787923, compoundYield 80.7%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 18 g. (0.2 moles) of methyl carbazate and 100 ml. of acetonitrile 33.7 g. (0.2 moles) of β-phenyl-propionyl chloride are added dropwise. The reaction mixture is heated to boiling for 15 hours, clarified and cooled. The crystals are filtered off. Thus 36.85 g. of the desired compound are obtained, yield 80.7%, m.p.: 118° C.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperaturecooled
  3. filtrationThe crystals are filtered off

Sources & evidence

ORD record
ord-e825e9d503154cf98f041cb3298fda70
Source dataset
uspto-grants-1989_04
Patent number
US04824670

Reaction notes

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