反应详情

1.3 g. (6.3 mMole) 7-amino-4,4-dimethylisoquinoline-1,3-dione was suspended in 30 ml. 2N acetic acid, mixed with 1.0 g. (12.5 mMole) potassium isocyanate and stirred for 6 hours at 80° C. The reaction mixture was cooled and the precipitate was filtered off with suction and washed with water. The residue was dissolved in dilute aqueous sodium hydroxide solution, the solution was neutralised with dilute hydrochloric acid, the residue was filtered off with suction and, for purification, worked up with ethanol and filtered off with suction. Yield: 0.6 g. (38.5% of theory); m.p. 260°-264° C.

1. temperatureThe reaction mixture was cooled
2. filtrationthe precipitate was filtered off with suction
3. washwashed with water
4. dissolutionThe residue was dissolved in dilute aqueous sodium hydroxide solution
5. filtrationthe residue was filtered off with suction and, for purification
6. filtrationfiltered off with suction