反应详情

1.3 g. (6.3 mmol) 7-Amino-4,4-dimethyl-isoquinolin-1,3-dione were dissolved in 30 ml. chloroform, mixed with 1.4 g. methyl isothiocyanate and boiled under reflux for 6 hours. The reaction mixture was then cooled and the precipitate was filtered off with suction and recrystallised from ethanol. Yield: 0.8 g. (46% of theory); m.p. 206°-207° C.

1. temperatureunder reflux for 6 hours
2. temperatureThe reaction mixture was then cooled
3. filtrationthe precipitate was filtered off with suction
4. customrecrystallised from ethanol