反应详情

5.5 g. (23 mMole) N-cyanodiphenoxyimidocarbonate and 4.7 g. (23 mMole) 7-amino-4,4-dimethylisoquinoline-1,3-dione were stirred in 110 ml. isopropanol for 16 hours at 50° C. Subsequently, the reaction mixture was cooled, filtered off with suction and washed with isopropanol. The residue was recrystallised from ethanol. There were obtained 4.1 g. (51% of theory) N-cyano-N'-(4,4-dimethyl-1,2,3,4-tetrahydro-1,3-dioxo-7-isoquinolinyl)-O-phenylisourea; m.p. 214°-216° C.

1. temperatureSubsequently, the reaction mixture was cooled
2. filtrationfiltered off with suction
3. washwashed with isopropanol
4. customThe residue was recrystallised from ethanol
5. customThere were obtained 4.1 g