反应详情

A mixture of 2,3-dihydro-8-methoxy-2-oxo-1H-3-benzazepine (12 g, 0.063 m) and 10% palladium-on-carbon (1.2 g) in acetic acid (200 ml) was shaken in an atmosphere of hydrogen (60 psi), degassed, filtered and concentrated in vacuo. The residue was dissolved in methylene chloride, washed with water, dried with magnesium sulfate and concentrated in vacuo. The residue was triturated with ether and filtered to give 8-methoxy-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine.

1. customdegassed
2. filtrationfiltered
3. concentrationconcentrated in vacuo
4. dissolutionThe residue was dissolved in methylene chloride
5. washwashed with water
6. dry with materialdried with magnesium sulfate
7. concentrationconcentrated in vacuo
8. customThe residue was triturated with ether
9. filtrationfiltered