反应详情

A mixture of 7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (4.3 g, 0.02 m) and sodium acetate (3.3 g, 0.04 m) in acetic anhydride (13 ml) was refluxed and stirred for 16 hours, concentrated in vacuo and partitioned between methylene chloride and water. The organic phase was dried with magnesium sulfate, filtered and concentrated in vacuo to give 3-acetyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine, m.p. 89°-90°.

1. temperaturewas refluxed
2. concentrationconcentrated in vacuo
3. custompartitioned between methylene chloride and water
4. dry with materialThe organic phase was dried with magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated in vacuo