HCID 21242880, compound → HCID 21242923, compound

HRID 621447Notes

Reaction equation

HRID 621447 reaction equation
[C:1]([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12](Br)[C:13]([O:19][CH3:20])=[C:14]([S:15]([CH3:18])(=[O:17])=[O:16])[C:7]=2[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[CH:12][C:13]([O:19][CH3:20])=[C:14]([S:15]([CH3:18])(=[O:16])=[O:17])[C:7]=2[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 21242880HCID 21242880, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21242923HCID 21242923, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 3-acetyl-8-bromo-7-methoxy-6-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (3.7 g, 0.01 m) and 10% palladium-on-carbon (0.37 g) in methanol (50 ml) is stirred in an atmosphere of hydrogen (60 psi) until uptake is complete. The mixture is degassed, filtered and concentrated in vacuo to give 3-acetyl-7-methoxy-6-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

Workup

  1. customThe mixture is degassed
  2. filtrationfiltered
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-92a9e2e7d2e24d2bac168932607f03c4
Source dataset
uspto-grants-1989_04
Patent number
US04824839

Reaction notes

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