Sodium Iodide → HCID 178448671, compound

Participants

Reaction Steps

To a mixture of 7-(2-benzyloxyethyl)-5-butyl-3-methylaminopyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (1.0 g, 2.7 mM) and sodium iodide (3 g, 20 mM) in acetonitrile (20 ml) was added dropwise trimethylsilyl chloride (2.6 g, 20 mM) at room temperature. The mixture was stirred at room temperature for 2 hours and poured onto ice-water to give crystals. Recrystallization from DMF/methanol/water gave pale yellow crystals (0.3 g, 40%), m.p. 248°-253° C.

Provenance & Evidence