Acetic Anhydride → HCID 14100203, compound

HRID 621487Notes

Reaction equation

HRID 621487 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][CH:24]=1)[CH2:5][N:6]1[C:11]2[NH:12][N:13]=[C:14]([NH:15][CH3:16])[C:10]=2[C:9](=[O:17])[N:8]([CH2:18][CH2:19][CH3:20])[C:7]1=[O:21].[C:25](OC(=O)C)(=[O:27])[CH3:26]>N1C=CC=CC=1>[C:25]([N:13]1[C:14]([NH:15][CH3:16])=[C:10]2[C:11]([N:6]([CH2:5][C:4]3[CH:22]=[CH:23][CH:24]=[C:2]([Cl:1])[CH:3]=3)[C:7](=[O:21])[N:8]([CH2:18][CH2:19][CH3:20])[C:9]2=[O:17])=[N:12]1)(=[O:27])[CH3:26]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178456466HCID 178456466, compound

Product 1

HCID 14100203HCID 14100203, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 7-(3-chlorobenzyl)-3-methylamino-5-propylpyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (1.0 g, 2.9 mM) and acetic anhydride (1.0 ml, 9.8 mM) in pyridine (15 ml) was stirred at 80° C. for 5 hours. The solution was concentrated to dryness and the residue was triturated with water (10 ml). Recrystallization from chloroform/ether gave colorless needles (0.95 g, 85%), m.p. 169°-171° C.

Workup

  1. concentrationThe solution was concentrated to dryness
  2. customthe residue was triturated with water (10 ml)
  3. customRecrystallization from chloroform/ether

Sources & evidence

ORD record
ord-358e7b9fdda1417d83ce1efd70d7fd7e
Source dataset
uspto-grants-1989_04
Patent number
US04824848

Reaction notes

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