Methyl iodide → HCID 14100209, compound

Participants

Reaction Steps

A mixture of 7-benzyl-5-butyl-3-methylaminopyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (1.5 g, 4.58 mM), methyl iodide (0.48 ml, 6 mM) and potassium carbonate (0.82 g, 6 mM) was stirred at room temperature for 12 hours. The mixture was concentrated to dryness and the residue was extracted with chloroform and water. The organic layer was washed with water, dried (MgSO4) and concentrated to dryness to give a solid. Recrystallization from 80% ethanol gave colorless needles (0.88 g, 50%), m.p. 146°-148° C.

Provenance & Evidence