Benzylamine → HCID 178448670, compound

Participants

Reaction Steps

A mixture of 5-butyl-7-(2-chloroethyl)-3-methylaminopyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (0.6 g, 2 mM) and benzylamine (0.66 ml, 6 mM) in dioxane (20 ml) was refluxed for 20 hours. The reaction solution was concentrated to dryness under reduced pressure to give a syrup, which was poured onto ice-water to give colorless crystals. The crystls were dissolved in 1N-HCl and insoluble material was filtered off, followed by addition of 1N-ammonia water to give crystals. Recrystallization from DMF/methanol/water afforded colorless needles (0.32 g, 43%), m.p. 198°-200° C.

Provenance & Evidence