Sodium bis(2-methoxyethoxy)aluminiumhydride → HCID 70390929, compound

HRID 621503Notes

Reaction equation

HRID 621503 reaction equation
[CH3:1][NH:2][C:3](=O)[CH2:4][C:5]1([NH:18][CH3:19])[S:17][CH:8]2[C:9]3[N:14]([CH2:15][CH2:16][CH:7]2[CH2:6]1)[CH2:13][CH:12]=[CH:11][CH:10]=3.[H-].COCCO[Al+]OCCOC.[Na+].[H-]>>[CH3:19][NH:18][C:5]1([CH2:4][CH2:3][NH:2][CH3:1])[S:17][CH:8]2[C:9]3[N:14]([CH2:15][CH2:16][CH:7]2[CH2:6]1)[CH2:13][CH:12]=[CH:11][CH:10]=3

Participants

3

Reactant 2

HCID 21584525Sodium bis(2-methoxyethoxy)aluminiumhydrideHCID 70390762HCID 70390762, compound

Product 1

HCID 70390929HCID 70390929, compoundYield 59%

Procedure

A mixture of 0.125 g (0.43 mmol) of (2RS,10bSR)-N-methyl-2-(2-methylamino-1,3,4,6,7,10b-hexahydrothieno[2,3-a]quinolizin-2-yl)acetamide and 0.51 ml (1.72 mmol) of 3.4M sodium bis(2-methoxyethoxy)aluminum hydride were reacted employing the procedure substantially described in Example 27 Step B to give 0.07 g (59%) of (2RS,10bSR)-2-methylamino-2-(2-methylaminoethyl)-1,3,4,6,7,10b-hexahydrothieno[2,3-a]quinolizine as a brown oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-918c3c09eff34664881cc4d7282640c6
Source dataset
uspto-grants-1989_04
Patent number
US04824849

Reaction notes

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