反应详情

A mixture of 6-(3,4-dimethoxyphenyl)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione (1.57 g) and phosphorus pentasulfide (3.3 g) in pyridine was refluxed for 15 hours with stirring. The reaction mixture was evaporated under reduced pressure. The residue was washed with 1N-hydrochloric acid and extracted with dichloromethane. The extract was washed with water, dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated in diisopropyl ether to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-1,3-dimethyl-4-thioxo-2(1H)-pyrimidinone (1.58 g).

1. temperaturewas refluxed for 15 hours
2. customThe reaction mixture was evaporated under reduced pressure
3. washThe residue was washed with 1N-hydrochloric acid
4. extractionextracted with dichloromethane
5. washThe extract was washed with water
6. dry with materialdried over magnesium sulfate
7. customevaporated under reduced pressure
8. customThe residue was triturated in diisopropyl ether