反应详情

A mixture of 6-(3,4-dimethoxyphenyl)-2-isopropoxy-3-methyl-4(3H)-pyrimidinone (2.5 g) and phosphorus pentasulfide (3.5 g) in pyridine (50 ml) was refluxed for 13 hours with stirring. The reaction mixture was evaporated under reduced pressure. The residue was washed with 1N-hydrochloric acid and extracted with chloroform. The extract was washed with water, dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated in ethanol and the resulting precipitate was triturated again in chloroform and collected by filtration to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)- 3-methyl-4-thioxo-2(1H)-pyrimidinone (0.27 g)

1. temperaturewas refluxed for 13 hours
2. customThe reaction mixture was evaporated under reduced pressure
3. washThe residue was washed with 1N-hydrochloric acid
4. extractionextracted with chloroform
5. washThe extract was washed with water
6. dry with materialdried over magnesium sulfate
7. customevaporated under reduced pressure
8. customThe residue was triturated in ethanol
9. customthe resulting precipitate was triturated again in chloroform
10. filtrationcollected by filtration