Acetic Anhydride → HCID 12899518, compound

HRID 621567Notes

Reaction equation

HRID 621567 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:20]=[CH:19][CH:18]=[C:17]3[C:12]=2[CH2:13][CH2:14][C:15](=[O:21])[NH:16]3)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:22](OC(=O)C)(=[O:24])[CH3:23]>C(O)(=O)C>[C:22]([N:4]1[CH2:5][CH2:6][N:1]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:20]=[CH:19][CH:18]=[C:17]3[C:12]=2[CH2:13][CH2:14][C:15](=[O:21])[NH:16]3)[CH2:2][CH2:3]1)(=[O:24])[CH3:23]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 14128502HCID 14128502, compound

Product 1

HCID 12899518HCID 12899518, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

20 grams of 5-(3-piperazinylpropoxy)-3,4-dihydrocarbostyril are mixed with 15 ml of acetic anhydride and 10 ml of acetic acid and heated for 5 hours under refluxing conditions. The reaction mixture is concentrated under reduced pressure to dryness. The residue is recrystallized from Ethanol to obtain 5-[3-(4-acetylpiperazinyl)propoxy]-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with a melting point of 143°-145° C.

Workup

  1. temperatureheated for 5 hours under refluxing conditions
  2. concentrationThe reaction mixture is concentrated under reduced pressure to dryness
  3. customThe residue is recrystallized from Ethanol

Sources & evidence

ORD record
ord-8fa58d99109b402cbc6407529d3f344a
Source dataset
uspto-grants-1989_04
Patent number
US04824840

Reaction notes

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