Pyridinium chloride → HCID 21243259, compound

HRID 621580Notes

Reaction equation

HRID 621580 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][C:19]2[C:22]3[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=3[S:24][C:18]=2[CH2:17]1.Cl.N1C=CC=CC=1>>[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][C:19]2[C:22]3[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=3[S:24][C:18]=2[CH2:17]1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 21243237HCID 21243237, compound

Product 1

HCID 21243259HCID 21243259, compound

Procedure

A mixture of 3.9 g of 2-[4-(5-methoxy-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine and 3.5 g of pyridine hydrochloride is stirred at 160° for 3 hours. After the usual working up, 2-[4-(5-hydroxy-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine is obtained.

Sources & evidence

ORD record
ord-6950e296833243eb88e08ddebcff6ce3
Source dataset
uspto-grants-1989_04
Patent number
US04824852

Reaction notes

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