HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 621603Generated: October 26, 2026
Glycinamide → N-(2-Amino-2-oxoethyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamide
https://huagongshe.com/reaction/621603
Participants
| Role | Name | HCID | Charge |
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| Reactant | Glycinamide | HCID 69020 | — |
| Reactant | Ethyl 2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetate | HCID 12365604 | — |
| Product | N-(2-Amino-2-oxoethyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamide | HCID 11701304 | 43.5% |
Reaction Steps
A mixture of ethyl 4-hydroxy-2-oxo-1-pyrrolidineacetate (0.5 g) and glycinamide (0.6 g) was stirred under nitrogen at 80° C. for 4 hours. After cooling, the mixture was chromatographed on a silica gel column, by eluting with dichloromethane/methanol 7:3, affording the title compound (250 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04824861 |
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| Source dataset | uspto-grants-1989_04 |
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| ORD ID | ord-76fda67fcc57443f940989b112aa1e45 |
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| Source note | uspto-grants-1989_04 |
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