Sodium Hydroxide → HCID 18632050, compound

Participants

Reaction Conditions

Reaction Steps

345 mg of 16α-fluoro-1β,6β-dimethyl-7-dimethylenandrost-4-ene-3,17-dione (its preparation is described in Example 2) is dissolved in methanol (20 ml) and the resulting solution cooled to 0° C. Thereupon ice cold 36% hydrogen peroxide (2 ml) and 2% sodium hydroxide (1 ml) are added. The mixture is stirred for about 24 hrs at 0°-5° C. and then poured into ice water. The product is filtered off, washed with water and then dried to give 4,5-epoxy-16α-fluoro-1β,6β-dimethyl-7-methylenandrostane-3,17-dione.

Provenance & Evidence