HRID621627

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID87253

Benzeneselenic anhydride

C12H10O3Se2

结构：C=C1[C@@H]2[C@H](CC[C@]3(C)C(=O)[C@H](F)C[C@@H]23)[C@@]2(C)[C@H](C)CC(=O)C3OC32[C@@H]1C

HCID18632050

未命名化合物

PRODUCTS

生成物

结构：C=C1[C@H]2[C@@H]3C[C@@H](F)C(=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)C(C)=CC(=O)C3OC32[C@@H]1C

HCID18632049

未命名化合物

收率 79.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID7964

Chlorobenzene

C6H5Cl

PROCEDURE

实验过程

A solution of 4,5-epoxy-16α-fluoro-1β,6β-dimethyl-7-methylenandrostane-3,17-dione (361 mg) and benzeneseleninic anhydride (360 mg) in chlorobenzene (30 ml) is heated for 4 hrs at 90°-100° C. Then the solvent is removed in vacuo and the residue chromatographed on silica gel to give 4,5-epoxy-16α-fluoro-1,6β-dimethyl-7-methylenandrost-1-ene-3,17-dione (287 mg).

WORKUP

后处理

customThen the solvent is removed in vacuo
customthe residue chromatographed on silica gel