反应详情

344 mg of 16α-fluoro-1β,7α-dimethyl-6-methylenandrost-4-ene-3,17-dione (which can be prepared as described in Example 1) are dissolved in methanol (20 ml) and the solution cooled to 0°-5° C. Ice cold 36% hydrogen peroxide (2 ml) and 2% sodium hydroxide (1 ml) are added and the mixture stirred for further 24 hrs at 0°-5° C. Then the mixture is poured into ice water, the product filtered off, washed with water and dried to yield 16α-fluoro-4,5-epoxy-1β,7α-dimethyl-6-methylenandrostane-3,17-dione (306 mg).

1. temperaturethe solution cooled to 0°-5° C
2. filtrationthe product filtered off
3. washwashed with water
4. customdried