反应详情

A mixture of 3-methyl-4-phenylthiobenzoic acid (85 g), conc. sulfuric acid (20 ml) and methanol (1.2 liter) is refluxed with stirring for 4 hours. After the reaction is completed, the reaction mixture is concentrated under reduced pressure. To the residue is added ethyl acetate (1.5 liter), and the mixture is washed with saturated aqueous sodium chloride solution (400 ml×3), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 3-methyl-4-phenylthiobenzoate (80.33 g).

1. temperatureis refluxed
2. concentrationthe reaction mixture is concentrated under reduced pressure
3. additionTo the residue is added ethyl acetate (1.5 liter)
4. washthe mixture is washed with saturated aqueous sodium chloride solution (400 ml×3)
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure