Water → HCID 178466107, compound

HRID 621649Notes

Reaction equation

HRID 621649 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]3[C:17]([OH:18])=[N:16][CH:15]=[N:14][C:13]=23)=[CH:5][CH:4]=1)[CH3:2].[OH2:19]>C(O)(=O)C.[O-2].[O-2].[O-2].[Cr+6]>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[N:11][N:12]3[C:17]([OH:18])=[N:16][CH:15]=[N:14][C:13]=23)=[CH:7][CH:8]=1)(=[O:19])[CH3:2]

Participants

5

Reactant 2

HCID 962Water2×HCID 178435841HCID 178435841, compound

Product 1

HCID 178466107HCID 178466107, compound

Reagents, catalysts & solvents 2

HCID 10219390chromium (VI) trioxideCatalystHCID 176Acetic AcidSolvent

Procedure

To a suspension of 8-(4-ethylphenyl)-4-hydroxypyrazolo[1,5-a]-1,3,5-triazine (240 mg) in acetic acid (5 ml) are added chromium trioxide (500 mg) and water (1 ml), and the mixture is stirred at room temperature for 14 hours. To the reaction mixture is added water, and the insoluble material is separated by filtration, washed with water and dried to give the title compound (150 mg).

Workup

  1. customthe insoluble material is separated by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-219fccb3130d4a538afcf4370fb92777
Source dataset
uspto-grants-1989_04
Patent number
US04824834

Reaction notes

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