Acetyl chloride → HCID 178475387, compound

HRID 621654Notes

Reaction equation

HRID 621654 reaction equation
[OH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13](OC)[CH:12]=3)=[C:6]2[N:5]=[CH:4][N:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[N+](C1C=CC=CC=1)([O-])=[O:24].[C:32](Cl)(=[O:34])[CH3:33]>>[C:32]([O:34][C:13]1[CH:12]=[C:11]([C:10]2[CH:9]=[N:8][N:7]3[C:2]([OH:1])=[N:3][CH:4]=[N:5][C:6]=23)[CH:16]=[CH:15][CH:14]=1)(=[O:24])[CH3:33]

Participants

5

Reactant 4

HCID 6367Acetyl chlorideHCID 7416NitrobenzeneHCID 6451240Aluminum(III) ChlorideHCID 178489848HCID 178489848, compound

Product 1

HCID 178475387HCID 178475387, compound

Procedure

A mixture of 4-hydroxy-8-(3-methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazine (242 mg), aluminum chloride (799 mg) and nitrobenzene (3 ml) is stirred at 80°-90° C. for 5 hours. To the reaction mixture is added acetyl chloride (0.12 ml). After reacting for 45 minutes, the reaction mixture is cooled and poured into ice water. The resulting precipitate is separated by filtration, washed with water and dried to give the title compound (8 mg).

Workup

  1. waitAfter reacting for 45 minutes
  2. temperaturethe reaction mixture is cooled
  3. customThe resulting precipitate is separated by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-7af45306f48c4e10af5102dbc4c8caea
Source dataset
uspto-grants-1989_04
Patent number
US04824834

Reaction notes

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