反应详情

To a solution of 1.21 g (5 mmol) of nicotinoyltyramine in 10 ml of acetone, 1.41 g (10 mmol) of methyl iodide were added and the mixture was refluxed while stirring for 6 hrs. The fine, yellow solid which separated was filtered and crystallized from methanol ether. Yield 1.78 g (93%), m.p. 208°-210° C. PMR (DMSO-d6 /D2O) δ 9.23-8.26 (m, 4H, C5H4N+), 7.33-6.83 (m, 4H, C6H4), 4.50 (s, 3H, ##STR1537## 3.70 (t, J=7 Hz, 2H, ##STR1538## 2.93 (t, J=7 Hz, 2H, CH2).

1. temperaturethe mixture was refluxed
2. customThe fine, yellow solid which separated
3. filtrationwas filtered
4. customcrystallized from methanol ether