HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-[(6-Methoxypyridin-2-yl)methyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 6-Methoxy-2-pyridinecarbonitrile | HCID 13023644 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | N-[(6-Methoxypyridin-2-yl)methyl]acetamide | HCID 13882972 | — |
Reaction Steps
A mixture of 1.0 g (7.46 mmole) of 2-cyano-6-methoxypyridine, 0.37 g (4.48 mole) of sodium acetate, 25 ml of acetic anhydride and about 1.0 g of Raney nickel was hydrogenated on a Parr apparatus for about 5.5 hours. The mixture was filtered, and then evaporated with warming in vacuo to provide 2-acetamidomethyl-6-methoxypyridine. The structural assignment was supported by infrared spectral analysis.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04824953 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-7464ff5199954099beafd8e15a1c8318 |
| Source note | uspto-grants-1989_04 |