反应详情

温度

0 °C

5 g of 4-hydroxy-4-(4-pyridyl)cyclohexanone ethylene acetal was dissolved in 40 ml of pyridine and 8 ml of thionyl chloride was added thereto at -10° C. The obtained mixture was stirred at 0° C. and poured onto ice and an excessive amount of an aqueous solution of sodium hydroxide was added thereto. After purifying the reaction mixture by extracting with methylene chloride, 4 g of 4-(4-pyridyl)cyclohex-3-enone ethylene acetal was obtained. m.p.: 67°-70° C. NMRδTMSCDCl3 : 1.86 (2H, t), 2.4-2.7 (4H, m), 4.04 (4H, s), 6.24 (1H, t), 7.28 (2H, d) and 8.52 (2H, d).

1. customat -10° C
2. additionpoured onto ice
3. customAfter purifying the reaction mixture
4. extractionby extracting with methylene chloride