6-Dimethylaminohexan-1-ol → HCID 53795635, compound

Participants

Reaction Steps

0.65 ml (5 meq) of hexyl isocyanate and 726 mg (5 meq) 6-(dimethylamino)hexanol are combined in 5 ml of tetrahydrofuran and reacted over a weekend at room temperature. The reaction mixture is evaporated under reduced pressure (<30° C.), dried in vacuo and the product purified by silica gel chromatography in the system CH2Cl2 :CH3OH:NH3 (65:25:4). Fractions 50-64 are combined, evaporated under reduced pressure <30° C. and dried in vacuo to yield 460 mg of title compound.

Provenance & Evidence